Hussey is also widely known by his nickname Mr Cricket. Hussey was a relative latecomer to both the one-day international and Test Australian teams, debuting at 28 and 30 years of age in the respective formats, with 15,313 first-class runs before making his Test debut. However, he had a highly successful international career, being the top-ranked ODI batsman in the world in 2006.
On 18 April 2006 Hussey set a record as the fastest player in terms of time to reach 1,000 Test runs. He reached the milestone in just 166 days. Hussey was also the fastest player to reach the top 10 of the LG ICC cricket ratings. He maintained an exceptional average of 105.25 in the 2006–07 Ashes series, which Australia won 5–0. Hussey plays for the IPL team Chennai Super Kings, and he became the second batsman to score a century in the competition, after New Zealand's Brendon McCullum. He scored 116 not out against the team Kings XI Punjab.